Abstract Microsponges are polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles with a large porous surface. Moreover, they may enhance stability, reduce side effects and modify drug release favorably. Microsponge technology has many favorable characteristics, which make it a versatile drug delivery vehicle. Microsponge Systems are based on microscopic, polymer-based microspheres that can suspend or entrap a wide variety of substances, and can then be incorporated into a formulated product such as a gel, cream, liquid or powder. The outer surface is typically porous, allowing a sustained flow of substances out of the sphere.
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Yadav and S. Various drug delivery systems like vesicles, microspheres, transdermal patches, nanoemulsions, microemulsions, microsponges etc. Microsponges are tiny sponge-like spherical particles with a large porous surface and provide controlled release. Herpes simplex is a viral disease occurring in two forms Herpes labialis and Herpes keratitis which occur on lips and epidermal layer of skin respectively.
Conventional formulations used for treating herpes have various drawbacks like irritation, rashes, frequency of dosing and low bioavailability. Hence microsponge loaded topical preparations herbal gel and medicated lipstick of Acyclovir was prepared with a purpose to overcome these drawbacks.
Microsponge loaded controlled release formulations of Acyclovir were prepared using quasi emulsion solvent diffusion method. The proposed formulations of Acyclovir loaded microsponges were characterized for particle size, production yield and entrapment efficiency.
The range of production yield was found to be between Porous structure of microsponges was confirmed by Scanning Electron Microscopy. After evaluation best optimized batch was incorporated in carbopol and aloe gel and lipstick base. Microsponge loaded herbal gel and lipstick were evaluated for various physical parameters. In- vitro release studies using diffusion cell revealed that the drug release followed Korsemeyer Peppas model. These are polymeric delivery systems composed of porous microspheres of an inert polymer that can entrap active ingredients and control their delivery rate.
The microsponges behave like a reservoir of the active ingredients. These can potentially be used for the controlled delivery of a large variety of substances such as fragrances, emollients, sunscreens, anti-inflammatory, antifungal, anti-microbial agents.
The outer surface is porous, allowing the sustained flow of substances out of the sphere. Microsponge delivery system MDS can provide increased efficacy for topically active agents with enhanced safety, extended product stability, enhanced formulation flexibility, reduced side effects and improved aesthetic properties in an efficient and novel manner. In addition these are non-irritating, non-mutagenic, non-allergenic, and non-toxic 6, 7, 8, 9, Acyclovir ACV , a guanine analogue, is a first-line antiviral drug for the treatment of infections caused by the herpes viruses.
The main drawbacks of currently available topical ACV creams are that they render evaporation of active ingredient from surface of skin, dry, cracked, or peeling lips, Dryness or flaking of treated skin, irritation, burning, stinging and itching 13, The aim of the present work was to develop a therapeutically effective topical delivery system, which is expected to overcome all these drawbacks.
A number of herbs are found to cure or help in the cure of Herpes. These herbs are: Aloe vera, Melissa officinalis, peppermint oil, tea tree oil, sandalwood. Therefore, the most prevalently reported herbs have been identified to be a part of the novel topical herbal formulation s of MDDS loaded Acyclovir Polysaccharides in Aloe stimulate white blood cell activity and increase the number of T-helper cells.
These cells coordinate the immune response, resulting in the production of antibodies and ridding the body of the infectious agent. Studies have also shown that an Anthroquinine called Emodin in Aloe Vera disables the functioning of herpes simplex virus type 1 and 2. Also it keeps the skin hydrated and reduces irritation in herpes 11, Solvents used are dichloromethane, ethyl alcohol, distilled water and as plasticizer triethyl citrate was used.
Method: Preparation of the Microsponges: Microsponges were prepared by quasi-emulsion solvent diffusion method using 22 factorial design as shown in table 2. PVA was weighed and added to distilled warm water and agitated to fully dissolve PVA in water and hence external phase was prepared. The ethyl cellulose was weighed and dissolved in dichloromethane and then drug was added to it and internal phase was prepared. Internal phase was added to external phase drop-wise during addition and after addition stirring was done with help of mechanical stirrer at rate of rpm for 2 hrs to evaporate Ethyl alcohol.
The dried microsponges were stored in vacuum desiccators to ensure the removal of residual content 1, 2, 6, 7, 8, 9,
Formulation and evaluation of curcumin microsponges for oral and topical drug delivery
Metrics details Abstract The aim of the present study was to improve the release rate of curcumin by microsponges prepared through quasi-emulsion solvent diffusion technique using ethylcellulose and PVA as carriers. The prepared microsponges were further filled in hard gelatin capsule shell and then loaded in carbopol gel to evaluate its potential in oral and topical drug delivery. Further, it was observed from the studies on release rate that microsponges filled in hard gelatin capsule shells batch MS4 showed Furthermore, the microsponges loaded in carbopol gel were evaluated for ex vivo drug deposition studies and it was found that The estimated drug remained in the skin was The drug release profile data were found to be fitted best into the zero-order model with anomalous transport mechanism of drug release in both cases. Microsponges have unique dissolution and compression properties due to their sponge-like texture Jangde
Dr. Ruchi Tiwari